Reduced production of polymeric immunoglobulin receptor in murine dextran sodium sulfate-induced colitis

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Reduced production of polymeric immunoglobulin receptor in murine dextran sodium sulfate-induced colitis.

Polymeric immunoglobulin receptor (pIgR) plays an intrinsic role in protecting the intestinal tract from invading pathogens. In the present study, we observed a decrease in pIgR in colon lysate from mice with dextran sodium sulfate (DSS) colitis. A decrease in pIgR was detected in both mRNA and protein levels. Histologic examinations revealed marked destruction of intestinal epithelial cells (I...

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ژورنال

عنوان ژورنال: Journal of Oral Science

سال: 2012

ISSN: 1880-4926,1343-4934

DOI: 10.2334/josnusd.54.23